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JmjC Domain-Containing Histone Demethylation Protein 2B (JHDM2b) Antibody
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Catalogue No: abx026585
Price:
US$326.25
(Size: 80 µl)
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Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe (II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Research Articles on JmjC Domain-Containing Histone Demethylation Protein 2B (JHDM2b)
| Target | JmjC Domain-Containing Histone Demethylation Protein 2B (JHDM2b) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 869-897 amino acids from the Central region of human JHDM2b. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q7LBC6 (UniProt, ExPASy) |
| UniProt Secondary AC | A6H8X7, Q9BVH6, Q9BW93, Q9BZ52, Q9NYF4, Q9UPS0 |
| UniProt Entry Name | KDM3B_HUMAN |
| KEGG | hsa:51780 |
| String | 9606.ENSP00000326563 |
| Molecular Weight | Calculated MW: 192 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse KDM3B. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |