Lysine-Specific Demethylase 3B (JMJD1B) Antibody

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Catalogue No: abx025664
Price: US$290.00
(Size: 80 µl)

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Datasheet SDS
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe (II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

Target Lysine-Specific Demethylase 3B (JMJD1B)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB
Host Rabbit
Recommended dilutions WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 25-57 amino acids from the N-terminal region of human JMJD1B.
Isotype IgG
Form Liquid
Purification Purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q7LBC6 (UniProt, ExPASy)
UniProt Secondary AC A6H8X7, Q9BVH6, Q9BW93, Q9BZ52, Q9NYF4, Q9UPS0
UniProt Entry Name KDM3B_HUMAN
KEGG hsa:51780
String 9606.ENSP00000326563
Molecular Weight Calculated MW: 192 kDa
Buffer PBS containing 0.09% sodium azide.
Specificity Predicted to react with Mouse KDM3B.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Lysine-Specific Demethylase 3B (JMJD1B)
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