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Histone Acetyltransferase Type B Catalytic Subunit (KAT1) Antibody
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Catalogue No: abx025916
Price:
US$326.25
(Size: 80 µl)
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Histone acetylation, particularly of histone H4, has been proposed to play an important role in replication-dependent nucleosome assembly. The HAT1 protein contains D, A, and B motifs, which are present in many N-acetyltransferases, including those that acetylate substrates other than histones. The HAT1 holoenzyme consists of 2 subunits: the catalytic 46-kD HAT1 and the accessory p46. The p46 subunit stimulated the activity of HAT1 and bound to core histones. The HAT1 holoenzyme acetylated newly synthesized but not nucleosomal histone H4 at lys5 and lys12, and, to a lesser extent, histone H2A at lys5. HAT1 and p46 polypeptides are located in the nucleus of S-phase cells. HAT1 may play a role in telomeric silencing.
Research Articles on Histone Acetyltransferase Type B Catalytic Subunit (KAT1)
| Target | Histone Acetyltransferase Type B Catalytic Subunit (KAT1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 389-419 amino acids from the C-terminal region of human KAT1 (HAT1). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O14929 (UniProt, ExPASy) |
| UniProt Secondary AC | Q49A44, Q53QF0, Q53SU4, Q6P594, Q8WWB9 |
| UniProt Entry Name | HAT1_HUMAN |
| Gene Symbol | HAT1 |
| KEGG | hsa:8520 |
| String | 9606.ENSP00000264108 |
| Molecular Weight | Calculated MW: 49.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Rat HAT1. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |