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Potassium Voltage-Gated Channel Subfamily J Member 11 (KCNJ11) Antibody
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Catalogue No: abx004413
Price:
US$348.00
(Size: 60 µl)
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KCNJ11 Antibody is a Rabbit Polyclonal antibody against KCNJ11. Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Research Articles on Potassium Voltage-Gated Channel Subfamily J Member 11 (KCNJ11)
| Target | Potassium Voltage-Gated Channel Subfamily J Member 11 (KCNJ11) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human KCNJ11 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q14654 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DWI4, E9PNK0, Q2M1H7, Q58EX3, Q8IW96 |
| UniProt Entry Name | KCJ11_HUMAN |
| Gene Symbol | KCNJ11 |
| GeneID | 3767 |
| NCBI Accession | NP_000516.3 |
| KEGG | hsa:3767 |
| String | 9606.ENSP00000345708 |
| Molecular Weight | Calculated MW: 33 kDa/43 kDa Observed MW: 31-43 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
