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ER Lumen Protein-Retaining Receptor 2 (KDELR2) Antibody
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Catalogue No: abx028251
Price:
US$290.00
(Size: 80 µl)
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Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
Research Articles on ER Lumen Protein-Retaining Receptor 2 (KDELR2)
| Target | ER Lumen Protein-Retaining Receptor 2 (KDELR2) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 183-211 amino acids from the C-terminal region of human KDELR2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P33947 (UniProt, ExPASy) |
| UniProt Secondary AC | A4D2P4, Q6IPC5, Q96E30 |
| UniProt Entry Name | ERD22_HUMAN |
| Gene Symbol | KDELR2 |
| GeneID | 11014 |
| OMIM | 609024 |
| HGNC | 6305 |
| KEGG | hsa:11014 |
| String | 9606.ENSP00000258739 |
| Molecular Weight | Calculated MW: 24.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Cow and Xenopus KDELR2. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |