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Lysine-Specific Demethylase 3A (KDM3A) Antibody
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Catalogue No: abx015903
Price:
US$420.50
(Size: 100 µl)
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This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. JMJD1A functions as a mono- and dimethylation-specific demethylase, binding iron and a-ketoglutarate as cofactors and demethylating Lysine 9 of Histone H3. This suggests that JMJD1A plays a central role in the histone code and participates in nuclear hormone receptor-based transcriptional regulation.In addition, JMJD1A plays an important role in the regulation of cell growth during development and in chromatin regulation. JMJD1A directly regulates the expression of TNP1 and Protamine 1 (proteins required for the proper packaging and condensation of sperm chromatin) and, therefore, plays an essential role in spermatogenesis.
Research Articles on Lysine-Specific Demethylase 3A (KDM3A)
| Target | Lysine-Specific Demethylase 3A (KDM3A) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human KDM3A expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9Y4C1 (UniProt, ExPASy) |
| UniProt Secondary AC | D6W5M3, Q53S72, Q68D47, Q68UT9, Q6N050, Q8IY08 |
| UniProt Entry Name | KDM3A_HUMAN |
| Gene Symbol | KDM3A |
| GeneID | 55818 |
| OMIM | 611512 |
| HGNC | 20815 |
| Ensembl | ENSG00000115548 |
| String | 9606.ENSP00000386660 |
| Molecular Weight | 147 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |