+44 (0) 1223 755950
+1 832 327 7413
Kinase D-Interacting Substrate of 220 kDa (KIDINS220) Antibody
REQUEST MORE INFO
Catalogue No: abx028694
Price:
US$326.25
(Size: 80 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
KIDINS220 promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin-and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
Research Articles on Kinase D-Interacting Substrate of 220 kDa (KIDINS220)
| Target | Kinase D-Interacting Substrate of 220 kDa (KIDINS220) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 1518-1547 amino acids from the C-terminal region of human KIDINS220. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9ULH0 (UniProt, ExPASy) |
| UniProt Secondary AC | A1L4N4, Q4VC08, Q6MZU2, Q9H889, Q9H9E4, Q9NT37, Q9UF42 |
| UniProt Entry Name | KDIS_HUMAN |
| Gene Symbol | KIDINS220 |
| String | 9606.ENSP00000256707 |
| Molecular Weight | Calculated MW: 197 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |