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Kinase Insert Domain Receptor Phospho-Tyr1175 (KDR pY1175) Antibody
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Catalogue No: abx239853
Price:
US$406.00
(Size: 100 µg)
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Kinase Insert Domain Receptor Phospho-Tyr1175 (KDR pY1175) Antibody is a Rabbit Polyclonal antibody for the detection of Phospho-VEGF Receptor 2-Y1175. KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.
Research Articles on Kinase Insert Domain Receptor Phospho-Tyr1175 (KDR pY1175)
| Target | Kinase Insert Domain Receptor Phospho-Tyr1175 (KDR pY1175) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A phospho specific peptide corresponding to residues surrounding Y1175 of human VEGF Receptor 2 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P35968 (UniProt, ExPASy) |
| UniProt Secondary AC | A2RRS0, B5A925, C5IFA0, O60723, Q14178 |
| UniProt Entry Name | VGFR2_HUMAN |
| Gene Symbol | KDR |
| GeneID | 3791 |
| OMIM | 191306 |
| HGNC | 6307 |
| KEGG | hsa:3791 |
| Ensembl | ENSG00000128052 |
| String | 9606.ENSP00000263923 |
| Molecular Weight | Observed MW: 250 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |