Calcium And Integrin-Binding Family Member 2 (CIB2) Antibody

DNA-dependent protein kinases (DNA-PK) play a role in the repair of double-strand DNA breaks and in the process of V (D) J recombination during lymphoid development. By EST database searching for sequences homologous to the DNA-PK gene KIP/CIB and 5-prime RACE, Seki, N et al. isolated a full-length cDNA, which they designated as KIP2, from a human fetal brain cDNA library. KIP2 encodes a deduced 187-amino acid protein with a predicted molecular mass of 22 kD. The KIP2 protein shares 46%, 39%, and 30% sequence identity with the calcium-binding proteins KIP/CIB, calcineurin B and calmodulin respectively. KIP2 contains two EF-hand motifs and a helix-loop-helix motif involved in coordinating the calcium ion, indicating that KIP2 may also bind calcium. KIP2 is ubiquitously expressed in various human tissues.

Target	Calcium And Integrin-Binding Family Member 2 (CIB2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 8-37 amino acids from the N-terminal region of human KIP2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O75838 (UniProt, ExPASy)
UniProt Secondary AC	B4DDF0, H0YM71, Q05BT6
UniProt Entry Name	CIB2_HUMAN
KEGG	hsa:10518
String	9606.ENSP00000258930
Molecular Weight	Calculated MW: 21.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Calcium And Integrin-Binding Family Member 2 (CIB2)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue