Prostate-Specific Antigen / PSA (KLK3) Antibody

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.

Target	Prostate-Specific Antigen / PSA (KLK3)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human KLK3 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P07288 (UniProt, ExPASy)
UniProt Secondary AC	C9JXH3, G3V0H4, G3XAE3, Q15096, Q16272, Q86TG8, Q8IXI4
UniProt Entry Name	KLK3_HUMAN
Gene Symbol	KLK3
GeneID	354
OMIM	176820
HGNC	6364
KEGG	hsa:354
Ensembl	ENSG00000142515
String	9606.ENSP00000314151
Enzyme Commission Number	EC 3.4.21.77
Molecular Weight	29 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Prostate-Specific Antigen / PSA (KLK3)

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