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Keratin, Type II Cuticular Hb6 (KRT86) Antibody
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Catalogue No: abx031387
Price:
US$326.25
(Size: 80 µl)
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The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.
Research Articles on Keratin, Type II Cuticular Hb6 (KRT86)
| Target | Keratin, Type II Cuticular Hb6 (KRT86) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 300-327 amino acids from the Central region of human KRT86. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O43790 (UniProt, ExPASy) |
| UniProt Secondary AC | P78387 |
| UniProt Entry Name | KRT86_HUMAN |
| Gene Symbol | KRT86 |
| KEGG | hsa:3892 |
| String | 9606.ENSP00000444533 |
| Molecular Weight | Calculated MW: 53.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Cow and Sheep KRT86. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |