Linker For Activation Of T-Cell (LAT) Antibody

LAT Antibody is a Rabbit Polyclonal antibody against LAT. The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.

Target	Linker For Activation Of T-Cell (LAT)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 95-262 of human LAT.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O43561 (UniProt, ExPASy)
UniProt Secondary AC	B7WPI0, C7C5T6, G5E9K3, O43919
UniProt Entry Name	LAT_HUMAN
Gene Symbol	LAT
GeneID	27040
NCBI Accession	NP_055202.1
KEGG	hsa:27040
Molecular Weight	Calculated MW: 28 kDa Observed MW: 35 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Linker For Activation Of T-Cell (LAT)

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