Leptin (LEP) Antibody

Leptin (LEP) Antibody is a Rabbit Polyclonal antibody for the detection of leptin.

Leptin is a protein that is secreted by white adipocytes,and which plays a major role in the regulation of body weight. Leptin is the most critical hormone in the homeostatic regulation of energy balance among those so far discovered. Leptin primarily acts on the neurons of the mediobasal part of hypothalamus to regulate food intake,thermogenesis, and the blood glucose level. Leptin also has several endocrine functions,and is involved in the regulation of immune and inflammatory responses,hematopoiesis,angiogenesis and wound healing.Mutations in this gene and/or its regulatory regions cause severe obesity,and morbid obesity with hypogonadism.Leptin has also been linked to type 2 diabetes mellitus development.

Target	Leptin (LEP)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	leptin
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P41159 (UniProt, ExPASy)
UniProt Secondary AC	O15158, Q56A88
UniProt Entry Name	LEP_HUMAN
Gene Symbol	LEP
GeneID	3952
OMIM	164160
HGNC	6553
KEGG	hsa:3952
Ensembl	ENSG00000174697
String	9606.ENSP00000312652
Molecular Weight	Observed MW: 18 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Leptin (LEP)

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