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Lectin-Galactoside Binding Soluble 3 (LGALS3) Antibody
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Catalogue No: abx001250
Price:
US$348.00
(Size: 60 µl)
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LGALS3 Antibody is a Rabbit Polyclonal antibody against LGALS3. Galectins are a family of soluble b-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) inter- actions and play a role in tumor progression, pre-mRNA splicing and apop-tosis. The galectin-3 protein, also known as Mac-2, hMac-2, GALBP, CBP35 or LGALS3, contains a single carbohydrate binding domain, which binds galactose-containing glycoconjugates. Galectin-3 is expressed in colonic and intestinal epithelium, inflammatory macrophages, papillary and follicular carcinomas, neoplastic astrocytes and some B and T lymphocytes. Upregulated expression of galectin-3 is involved in cancer progression and metastasis. Galectin-3 mediates the endocytosis of ∫1 Integrins in a lactose-dependent manner and is associated with thyroid malignancy and Crohn’s disease. It may also be used as a marker for diagnosing cases involving Hurthle cell adenomas and carcinomas.
Research Articles on Lectin-Galactoside Binding Soluble 3 (LGALS3)
| Target | Lectin-Galactoside Binding Soluble 3 (LGALS3) |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human LGALS3 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P17931 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RC38, Q16005, Q6IBA7, Q96J47 |
| UniProt Entry Name | LEG3_HUMAN |
| Gene Symbol | LGALS3 |
| GeneID | 3958 |
| NCBI Accession | NP_002297.2 |
| KEGG | hsa:3958 |
| String | 9606.ENSP00000254301 |
| Molecular Weight | Calculated MW: 26 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |