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DNA Ligase 4 (LIG4) Antibody
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Catalogue No: abx034651
Price:
US$326.25
(Size: 80 µl)
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Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V (D) J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
Research Articles on DNA Ligase 4 (LIG4)
| Target | DNA Ligase 4 (LIG4) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 239-267 amino acids from the N-terminal region of human LIG4. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P49917 (UniProt, ExPASy) |
| UniProt Secondary AC | Q8IY66, Q8TEU5 |
| UniProt Entry Name | DNLI4_HUMAN |
| KEGG | hsa:3981 |
| String | 9606.ENSP00000484288 |
| Molecular Weight | Calculated MW: 104 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |