+44 (0) 1223 755950
+1 832 327 7413
LIM Domain Kinase 2 (LIMK2) Antibody
REQUEST MORE INFO
Catalogue No: abx004143
Price:
US$203.00
(Size: 20 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
LIMK2 Antibody is a Rabbit Polyclonal antibody against LIMK2. There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.
Research Articles on LIM Domain Kinase 2 (LIMK2)
| Target | LIM Domain Kinase 2 (LIMK2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human LIMK2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P53671 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K6H5, Q7KZ80, Q7L3H5, Q96E10, Q99464, Q9UFU0 |
| UniProt Entry Name | LIMK2_HUMAN |
| Gene Symbol | LIMK2 |
| GeneID | 3985 |
| NCBI Accession | NP_001026971.1 |
| KEGG | hsa:3985 |
| String | 9606.ENSP00000339916 |
| Molecular Weight | Calculated MW: 72 kDa Observed MW: 80 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |