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Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha Factor (LITAF) Antibody
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Catalogue No: abx004189
Price:
US$232.00
(Size: 20 µl)
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LITAF Antibody is a Rabbit Polyclonal antibody against LITAF. Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene.
Research Articles on Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha Factor (LITAF)
| Target | Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha Factor (LITAF) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB, IHC, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IP: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-161 of human LITAF. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q99732 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DUG1, G5E9K0, Q05DW0, Q9C0L6 |
| UniProt Entry Name | LITAF_HUMAN |
| Gene Symbol | LITAF |
| GeneID | 9516 |
| NCBI Accession | NP_004853.2 |
| KEGG | hsa:9516 |
| String | 9606.ENSP00000459533 |
| Molecular Weight | Calculated MW: 17 kDa Observed MW: 23 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |