Lamin A (LMNA) Antibody

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Catalogue No: abx000634
Price: US$348.00
(Size: 60 µl)
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Western blot analysis of extracts of various cell lines using Lamin A/C Antibody (1/1000 dilution). HeLa cells were treated by Hydroxyurea (4 mM) at 37°C for 20 hours or treated by Paclitaxel (100 nM/ml) at 37°C for 20 hours. C6 cells were treated by Hydroxyurea (4 mM) at 37°C for 20 hours or treated by Paclitaxel (100 nM) at 37°C for 20 hours.
Lamin A (LMNA) Antibody Lamin A (LMNA) Antibody Lamin A (LMNA) Antibody Lamin A (LMNA) Antibody Lamin A (LMNA) Antibody Lamin A (LMNA) Antibody Lamin A (LMNA) Antibody Lamin A (LMNA) Antibody

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Datasheet SDS
LMNA Antibody is a Rabbit Polyclonal antibody against LMNA. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Target Lamin A (LMNA)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein corresponding to human Lamin C
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P02545 (UniProt, ExPASy)
UniProt Entry Name LMNA_HUMAN
Gene Symbol LMNA
GeneID 4000
NCBI Accession NP_733821.1
KEGG hsa:4000
String 9606.ENSP00000357283
Molecular Weight Calculated MW: 62-74 kDa
Observed MW: 69 kDa/72 kDa
Buffer PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration 1 mg/ml
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Lamin A (LMNA)
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