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Lamin B1 (LMNB1) Antibody
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Catalogue No: abx001562
Price:
US$217.50
(Size: 20 µl)
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LMNB1 Antibody is a Rabbit Polyclonal antibody against LMNB1. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).
Research Articles on Lamin B1 (LMNB1)
| Target | Lamin B1 (LMNB1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC, IP, ChIP |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, IP: 0.5 µg - 4 µg antibody per 200 µg - 400 µg extracts of whole cells, ChIP: 5 µg antibody per 10 µg - 15 µg of Chromatin. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 397-586 of human Lamin B1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P20700 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R6J6, Q3SYN7, Q96EI6 |
| UniProt Entry Name | LMNB1_HUMAN |
| Gene Symbol | LMNB1 |
| GeneID | 4001 |
| NCBI Accession | NP_005564.1 |
| KEGG | hsa:4001 |
| String | 9606.ENSP00000261366 |
| Molecular Weight | Calculated MW: 66 kDa Observed MW: 68/45 kDa |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
