Lymphocyte-Oriented Kinase (LOK) Antibody

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.

Target	Lymphocyte-Oriented Kinase (LOK)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 692-721 amino acids from the C-terminal region of human LOK.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O94804 (UniProt, ExPASy)
UniProt Secondary AC	A6ND35, B2R8F5, B3KMY1, Q6NSK0, Q9UIW4
UniProt Entry Name	STK10_HUMAN
KEGG	hsa:6793
String	9606.ENSP00000176763
Molecular Weight	Calculated MW: 112 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Lymphocyte-Oriented Kinase (LOK)

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