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Low Density Lipoprotein Receptor Related Protein 6 (LRP6) Antibody
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Catalogue No: abx032705
Price:
US$108.75
(Size: 20 µl)
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LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
Research Articles on Low Density Lipoprotein Receptor Related Protein 6 (LRP6)
| Target | Low Density Lipoprotein Receptor Related Protein 6 (LRP6) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 1531-1560 amino acids from the C-terminal region of human LRP6. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by saturated ammonium sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O75581 (UniProt, ExPASy) |
| UniProt Secondary AC | Q17RZ2 |
| UniProt Entry Name | LRP6_HUMAN |
| Gene Symbol | LRP6 |
| GeneID | 4040 |
| NCBI Accession | NP_002327.2 |
| KEGG | hsa:4040 |
| String | 9606.ENSP00000261349 |
| Molecular Weight | Calculated MW: 180 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |