Lysine-Specific Histone Demethylase 1A (LSD1) Antibody

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Catalogue No: abx026646
Price: US$326.25
(Size: 80 µl)
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Lysine-Specific Histone Demethylase 1A (LSD1) Antibody
Lysine-Specific Histone Demethylase 1A (LSD1) Antibody Lysine-Specific Histone Demethylase 1A (LSD1) Antibody Lysine-Specific Histone Demethylase 1A (LSD1) Antibody

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Datasheet SDS
LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes.

Target Lysine-Specific Histone Demethylase 1A (LSD1)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications ELISA, WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/1000, IHC-P: 1/50 - 1/100, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 108-142 amino acids from the N-terminal region of human LSD1.
Isotype IgG
Form Liquid
Purification Purified Rabbit Polyclonal Antibody.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O60341 (UniProt, ExPASy)
UniProt Entry Name KDM1A_HUMAN
KEGG hsa:23028
String 9606.ENSP00000383042
Molecular Weight Calculated MW: 92.9 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Lysine-Specific Histone Demethylase 1A (LSD1)


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