Lysyl Oxidase Like 1 (LOXL1) Antibody

Lysyl Oxidase Like 1 (LOXL1) Antibody is a Rabbit Polyclonal antibody for the detection of LOXL1.

This gene encodes a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome.

Target	Lysyl Oxidase Like 1 (LOXL1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	lysyl oxidase-like 1
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	Q08397 (UniProt, ExPASy)
UniProt Secondary AC	Q6NUL3, Q96BW7
UniProt Entry Name	LOXL1_HUMAN
Gene Symbol	LOXL1
GeneID	4016
KEGG	hsa:4016
String	9606.ENSP00000261921
Molecular Weight	Observed MW: 70 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Lysyl Oxidase Like 1 (LOXL1)

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