MAP2K1 / MAP2K2 (pS217 / S221) Antibody

MAP2K1/MAP2K2 (pS217/S221) Antibody is a Rabbit Polyclonal antibody against MAP2K1/MAP2K2 (pS217/S221). The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Target	MAP2K1/MAP2K2 (pS217/S221)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/2000 - 1/7000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic phosphorylated peptide around S217 & S221 of human MAP2K1/MAP2K2MAP2K1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q02750 (UniProt, ExPASy) P36507 (UniProt, ExPASy)
Gene Symbol	MAP2K1, MAP2K2
GeneID	5604/ 5605
NCBI Accession	NP_002746.1
Molecular Weight	Calculated MW: 40/43/44 kDa Observed MW: 44 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on MAP2K1/MAP2K2 (pS217/S221)

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