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Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) Antibody
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Catalogue No: abx016035
Price:
US$420.50
(Size: 100 µl)
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MAP2K4 (mitogen-activated protein kinase kinase 4), which is located on chromosome 17p11.2, with 399-amino acid protein (about 45 kDa), belongs to the family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified.MEK-4 (also called MEK4/MKK4) activates both p38 and JNK MAP kinases.MKK4 is a central mediator in the stress activated protein kinase signaling pathway that responds to a number of cellular and environmental stressors.By phosphorylating MAP kinases such as JNK,MKK4 can ultimately transmit stress signals to nuclear transcription factors that mediate various processes including proliferation, apoptosis, and differentiation.Its distinct biological functions have been identified for MKK4 including a role in development, hepatogenesis, and metastasis suppression.
Research Articles on Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4)
| Target | Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of MAP2K4 expressed in E. coli. |
| Isotype | IgM |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P45985 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R7N7, B3KYB2, D3DTS5, Q5U0B8, Q6FHX4, Q6P9H2, Q6PIE6 |
| UniProt Entry Name | MP2K4_HUMAN |
| Gene Symbol | MAP2K4 |
| GeneID | 6416 |
| OMIM | 601335 |
| HGNC | 6844 |
| KEGG | hsa:6416 |
| Ensembl | ENSG00000065559 |
| String | 9606.ENSP00000410402 |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |