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Mitogen-Activated Protein Kinase Kinase Kinase 9 (MAP3K9) Antibody
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Catalogue No: abx033795
Price:
US$290.00
(Size: 80 µl)
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Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
Research Articles on Mitogen-Activated Protein Kinase Kinase Kinase 9 (MAP3K9)
| Target | Mitogen-Activated Protein Kinase Kinase Kinase 9 (MAP3K9) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 159-189 amino acids from the N-terminal region of human MAP3K9. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P80192 (UniProt, ExPASy) |
| UniProt Secondary AC | A3KN85, Q0D2G7, Q6EH31, Q9H2N5 |
| UniProt Entry Name | M3K9_HUMAN |
| NCBI Accession | NP_149132.2 |
| KEGG | hsa:4293 |
| String | 9606.ENSP00000451263 |
| Molecular Weight | Calculated MW: 122 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse MAP3K9. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |