MEK Kinase Kinase 3 (MAP4K3) Antibody

MAP4K3 encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3).

Target	MEK Kinase Kinase 3 (MAP4K3)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant protein encoding human MAP4K3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by protein affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q8IVH8 (UniProt, ExPASy)
UniProt Secondary AC	Q6IQ39, Q8IVH7, Q9UDM5, Q9Y6R5
UniProt Entry Name	M4K3_HUMAN
Gene Symbol	MAP4K3
NCBI Accession	NP_001257354.1 NP_003609.2
KEGG	hsa:8491
String	9606.ENSP00000263881
Molecular Weight	Calculated MW: 101 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on MEK Kinase Kinase 3 (MAP4K3)

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