MEK Kinase Kinase 4 (MAP4K4) Antibody

MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4.The protein encoded by this gene is a member of the serine/threonine protein kinase family.This kinase has been shown to specifically activate MAPK8/JNK.The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway.Alternatively spliced transcript variants encoding different isoforms have been identified.

Target	MEK Kinase Kinase 4 (MAP4K4)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA
Host	Mouse
Recommended dilutions	ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of MAP4K4 (aa400-500) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O95819 (UniProt, ExPASy)
UniProt Secondary AC	E7ESS2, O75172, Q9NST7
UniProt Entry Name	M4K4_HUMAN
Gene Symbol	MAP4K4
GeneID	9448
OMIM	604666
HGNC	6866
KEGG	hsa:9448
Ensembl	ENSG00000071054
String	9606.ENSP00000343658
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on MEK Kinase Kinase 4 (MAP4K4)

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