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Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Phospho-Ser629 (MAP4K4 pS629) Antibody
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Catalogue No: abx031979
Price:
US$326.25
(Size: 80 µl)
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M4K4, a member of the STE20 subfamily of Ser/Thr protein kinases, may play a role in the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain of the adapter proteins Nck. HGK binds, via its CNH regulatory domain, to the N-terminal region of SPG3A. Expression appears to be ubiquitous, expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain, and isoform 4 is predominant in the liver, skeletal muscle and placenta.
Research Articles on Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Phospho-Ser629 (MAP4K4 pS629)
| Target | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Phospho-Ser629 (MAP4K4 pS629) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, DB |
| Host | Rabbit |
| Recommended dilutions | DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S629 of human MAP4K4. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by protein A affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with peptides. The antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O95819 (UniProt, ExPASy) |
| UniProt Secondary AC | E7ESS2, O75172, Q9NST7 |
| UniProt Entry Name | M4K4_HUMAN |
| Gene Symbol | MAP4K4 |
| GeneID | 9448 |
| OMIM | 604666 |
| HGNC | 6866 |
| KEGG | hsa:9448 |
| Ensembl | ENSG00000071054 |
| String | 9606.ENSP00000343658 |
| Enzyme Commission Number | EC 2.7.11.1 |
| Molecular Weight | Calculated MW: 142 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
