Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1) Antibody

MAPK1 is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets.

Target	Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 316-345 amino acids from the C-terminal region of human MAPK1.
Isotype	IgG
Form	Liquid
Purification	This antibody is purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P28482 (UniProt, ExPASy)
UniProt Secondary AC	A8CZ64
UniProt Entry Name	MK01_HUMAN
NCBI Accession	NP_002736.3 NP_620407.1
KEGG	hsa:5594
String	9606.ENSP00000215832
Molecular Weight	Calculated MW: 41.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat and Cow MAPK1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mitogen-Activated Protein Kinase 1 / ERK2 (MAPK1)

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