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Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10) Antibody
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Catalogue No: abx011782
Price:
US$420.50
(Size: 100 µl)
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The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. beta arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Research Articles on Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10)
| Target | Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10) |
| Clonality | Monoclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human MAPK10 (aa28-233) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P53779 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NFS3, A6NG28, B3KQ94, Q15707, Q49AP1 |
| UniProt Entry Name | MK10_HUMAN |
| GeneID | 5602 |
| KEGG | hsa:5602 |
| String | 9606.ENSP00000352157 |
| Enzyme Commission Number | EC 2.7.11.24 |
| Molecular Weight | 53 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |