Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10) Antibody

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. beta arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Target	Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10)
Clonality	Monoclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IF/ICC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human MAPK10 (aa28-233) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P53779 (UniProt, ExPASy)
UniProt Secondary AC	A6NFS3, A6NG28, B3KQ94, Q15707, Q49AP1
UniProt Entry Name	MK10_HUMAN
GeneID	5602
KEGG	hsa:5602
String	9606.ENSP00000352157
Enzyme Commission Number	EC 2.7.11.24
Molecular Weight	53 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mitogen-Activated Protein Kinase 10 / JNK3 (MAPK10)

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