Mitogen-Activated Protein Kinase 14 (MAPK14) Antibody

P38 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.

Target	Mitogen-Activated Protein Kinase 14 (MAPK14)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IF/ICC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 295-324 amino acids from the C-terminal region of human MAPK14.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q16539 (UniProt, ExPASy)
UniProt Entry Name	MK14_HUMAN
NCBI Accession	NP_001306.1 NP_620581.1 NP_620582.1 NP_620583.1
KEGG	hsa:1432
String	9606.ENSP00000229795
Molecular Weight	Calculated MW: 41.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse MAPK14.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Mitogen-Activated Protein Kinase 14 (MAPK14)

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