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Mitogen-Activated Protein Kinase 14 (MAPK14) Antibody
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Catalogue No: abx033466
Price:
US$326.25
(Size: 80 µl)
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P38 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.
Research Articles on Mitogen-Activated Protein Kinase 14 (MAPK14)
| Target | Mitogen-Activated Protein Kinase 14 (MAPK14) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IF/ICC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 295-324 amino acids from the C-terminal region of human MAPK14. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q16539 (UniProt, ExPASy) |
| UniProt Entry Name | MK14_HUMAN |
| NCBI Accession | NP_001306.1 NP_620581.1 NP_620582.1 NP_620583.1 |
| KEGG | hsa:1432 |
| String | 9606.ENSP00000229795 |
| Molecular Weight | Calculated MW: 41.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse MAPK14. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |