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Mitogen-Activated Protein Kinase 14 Phospho-Tyr322 (MAPK14 pY322) Antibody
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Catalogue No: abx000137
Price:
US$232.00
(Size: 20 µl)
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MAPK14 (pY322) Antibody is a Rabbit Polyclonal antibody against MAPK14 (pY322). The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Research Articles on Mitogen-Activated Protein Kinase 14 Phospho-Tyr322 (MAPK14 pY322)
| Target | Mitogen-Activated Protein Kinase 14 Phospho-Tyr322 (MAPK14 pY322) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic phosphorylated peptide around Y322 of human p38 MAPK. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q16539 (UniProt, ExPASy) |
| UniProt Entry Name | MK14_HUMAN |
| Gene Symbol | MAPK14 |
| GeneID | 1432 |
| NCBI Accession | NP_620581.1 |
| KEGG | hsa:1432 |
| String | 9606.ENSP00000229795 |
| Molecular Weight | Calculated MW: 41 kDa Observed MW: 41 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |