+44 (0) 1223 755950
+1 832 327 7413
Mitogen-Activated Protein Kinase 8 / JNK1 (MAPK8) Antibody
REQUEST MORE INFO
Catalogue No: abx033441
Price:
US$326.25
(Size: 80 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
JNK1 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.
Research Articles on Mitogen-Activated Protein Kinase 8 / JNK1 (MAPK8)
| Target | Mitogen-Activated Protein Kinase 8 / JNK1 (MAPK8) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 358-389 amino acids from the C-terminal region of human MAPK8. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P45983 (UniProt, ExPASy) |
| UniProt Entry Name | MK08_HUMAN |
| NCBI Accession | NP_001265476.1 NP_002741.1 NP_620634.1 NP_620637.1 |
| KEGG | hsa:5599 |
| String | 9606.ENSP00000378974 |
| Molecular Weight | Calculated MW: 48.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat MAPK8. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |