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Mitogen-Activated Protein Kinase 8 / JNK1 (MAPK8) Antibody
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Catalogue No: abx000671
Price:
US$203.00
(Size: 20 µl)
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MAPK8 Antibody is a Rabbit Polyclonal antibody against MAPK8. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.
Research Articles on Mitogen-Activated Protein Kinase 8 / JNK1 (MAPK8)
| Target | Mitogen-Activated Protein Kinase 8 / JNK1 (MAPK8) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 245-345 of human JNK1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P45983 (UniProt, ExPASy) |
| UniProt Entry Name | MK08_HUMAN |
| Gene Symbol | MAPK8 |
| GeneID | 5599 |
| NCBI Accession | NP_620635.1 |
| KEGG | hsa:5599 |
| String | 9606.ENSP00000378974 |
| Molecular Weight | Calculated MW: 48 kDa Observed MW: 44 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |