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Mitogen-Activated Protein Kinase 8/9/10 Phospho-Thr183/Tyr185/Thr221 (MAPK8/9/10 pT183/Y185/T221) Antibody
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Catalogue No: abx000327
Price:
US$246.50
(Size: 20 µl)
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MAPK8/9/10 (pT183/Y185/T221) Antibody is a Rabbit Polyclonal antibody against MAPK8 (pT183/Y185), MAPK9 (pT183/Y185) and MAPK10 (T221). Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: a-1 and a-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 a-2, and JUND binds only weakly to it. /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity.
Research Articles on Mitogen-Activated Protein Kinase 8/9/10 Phospho-Thr183/Tyr185/Thr221 (MAPK8/9/10 pT183/Y185/T221)
| Target | Mitogen-Activated Protein Kinase 8/9/10 Phospho-Thr183/Tyr185/Thr221 (MAPK8/9/10 pT183/Y185/T221) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A phospho specific peptide corresponding to residues surrounding T183 of human JNK1 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P45983 (UniProt, ExPASy) P45984 (UniProt, ExPASy) P53779 (UniProt, ExPASy) |
| Gene Symbol | MAPK8, MAPK9, MAPK10 |
| GeneID | 5599/5601/5602 |
| Molecular Weight | Calculated MW: 35/44/48/27/52 kDa Observed MW: 46 kDa, 54 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |