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Membrane Associated Ring-CH-Type Finger 1 (MARCHF1) Antibody
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Catalogue No: abx027985
Price:
US$326.25
(Size: 80 µl)
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MARCHF1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCHF1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).
Research Articles on Membrane Associated Ring-CH-Type Finger 1 (MARCHF1)
| Target | Membrane Associated Ring-CH-Type Finger 1 (MARCHF1) |
| Clonality | Polyclonal |
| Reactivity | Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 163-191 amino acids from the Central region of human MARCH1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q8TCQ1 (UniProt, ExPASy) Q6NZQ8 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DP29, Q9NWR0 |
| UniProt Entry Name | MARH1_HUMAN, MARH1_MOUSE |
| Gene Symbol | MARCHF1 |
| GeneID | 55016 72925 |
| NCBI Accession | NP_060393.1 NP_001159845.1 |
| KEGG | hsa:55016 |
| String | 9606.ENSP00000427223 |
| Molecular Weight | Calculated MW: 32.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |