Serine/Threonine-Protein Kinase MARK1 (MARK1) Antibody

MARK is a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration. Expression of MARK causes the phosphorylation of MAPs at their KXGS motifs, thereby detaching MAPs from the microtubules and thus facilitating the transport of particles. This occurs without impairing the intrinsic activity of motors because the velocity during active movement remains unchanged. In primary retinal ganglion cells, transfection with tau leads to the inhibition of axonal transport of mitochondria, APP vesicles, and other cell components which leads to starvation of axons and vulnerability against stress. This transport inhibition can be rescued by phosphorylating tau with MARK.

Target	Serine/Threonine-Protein Kinase MARK1 (MARK1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 671-700 amino acids from the C-terminal region of human MARK1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9P0L2 (UniProt, ExPASy)
UniProt Secondary AC	D3DTB0, D3DTB1, Q2HIY1, Q5VTF9, Q5VTG0, Q96SW9, Q9P251
UniProt Entry Name	MARK1_HUMAN
NCBI Accession	NP_061120.3
String	9606.ENSP00000483424
Molecular Weight	Calculated MW: 89 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Serine/Threonine-Protein Kinase MARK1 (MARK1)

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