Methyl-CpG Binding Domain Protein 2 (MBD2) Antibody

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.

Target	Methyl-CpG Binding Domain Protein 2 (MBD2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IF/ICC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 250-279 amino acids from the Central region of human MBD2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9UBB5 (UniProt, ExPASy)
UniProt Secondary AC	O95242, Q9UIS8
UniProt Entry Name	MBD2_HUMAN
Gene Symbol	MBD2
String	9606.ENSP00000256429
Molecular Weight	Calculated MW: 43.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse MBD2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Methyl-CpG Binding Domain Protein 2 (MBD2)

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