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Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1) Antibody
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Catalogue No: abx005320
Price:
US$217.50
(Size: 20 µl)
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MBTPS1 Antibody is a Rabbit Polyclonal antibody against MBTPS1. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction.
Research Articles on Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1)
| Target | Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 803-1052 of human MBTPS1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q14703 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K6V8, Q24JQ2, Q9UF67 |
| UniProt Entry Name | MBTP1_HUMAN |
| Gene Symbol | MBTPS1 |
| GeneID | 8720 |
| OMIM | 603355 |
| NCBI Accession | NP_003782.1 |
| HGNC | 15456 |
| KEGG | hsa:8720 |
| Ensembl | ENSG00000140943 |
| String | 9606.ENSP00000344223 |
| Molecular Weight | Calculated MW: 118 kDa Observed MW: 118 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |