+44 (0) 1223 755950
+1 832 327 7413
Melanoma Cell Adhesion Molecule (MCAM) Antibody
REQUEST MORE INFO
Catalogue No: abx015923
Price:
US$420.50
(Size: 100 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
The protein encoded by this gene plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue.Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread.Could be an adhesion molecule active in neural crest cells during embryonic development.Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Research Articles on Melanoma Cell Adhesion Molecule (MCAM)
| Target | Melanoma Cell Adhesion Molecule (MCAM) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human MCAM (AA: 84-189) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P43121 (UniProt, ExPASy) |
| UniProt Secondary AC | O95812, Q59E86, Q6PHR3, Q6ZTR2 |
| UniProt Entry Name | MUC18_HUMAN |
| Gene Symbol | MCAM |
| GeneID | 4162 |
| OMIM | 155735 |
| HGNC | 6934 |
| KEGG | hsa:4162 |
| Ensembl | ENSG00000076706 |
| String | 9606.ENSP00000264036 |
| Molecular Weight | 71.6 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |