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Melanoma Cell Adhesion Molecule (MCAM) Antibody
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Catalogue No: abx031695
Price:
US$326.25
(Size: 80 µl)
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MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. It could be an adhesion molecule active in neural crest cells during embryonic development. It acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
Research Articles on Melanoma Cell Adhesion Molecule (MCAM)
| Target | Melanoma Cell Adhesion Molecule (MCAM) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 532-558 amino acids from the C-terminal region of human MCAM. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P43121 (UniProt, ExPASy) |
| UniProt Secondary AC | O95812, Q59E86, Q6PHR3, Q6ZTR2 |
| UniProt Entry Name | MUC18_HUMAN |
| Gene Symbol | MCAM |
| KEGG | hsa:4162 |
| String | 9606.ENSP00000264036 |
| Molecular Weight | Calculated MW: 71.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |