C-C Motif Chemokine 2 / MCP1 (CCL2) Antibody

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Catalogue No: abx011184
Price: US$427.75
(Size: 100 µl)

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Datasheet SDS
Monocyte chemoattractant protein-1 (CCL2) is a member of the chemokine beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic CCL2 signal pathway in vivo may prevent PH.

Target C-C Motif Chemokine 2 / MCP1 (CCL2)
Clonality Monoclonal
Reactivity Human
Tested Applications ELISA
Host Mouse
Recommended dilutions ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Purified recombinant fragment of human MCP-1 expressed in E. coli.
Isotype IgG1 Kappa
Form Liquid
Purification Unpurified ascites.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P13500 (UniProt, ExPASy)
UniProt Secondary AC B2R4V3, Q9UDF3
UniProt Entry Name CCL2_HUMAN
Gene Symbol CCL2
GeneID 6347
OMIM 158105
NCBI Accession NP_002973.1 NM_002982.3
HGNC 10618
KEGG hsa:6347
Ensembl ENSG00000108691
String 9606.ENSP00000225831
Molecular Weight 13 kDa
Buffer Ascitic fluid containing 0.03% sodium azide.
Concentration Not determined.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on C-C Motif Chemokine 2 / MCP1 (CCL2)
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