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Mdm2 p53 Binding Protein Homolog Phospho-Ser260 (MDM2 pS260) Antibody
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Catalogue No: abx000147
Price:
US$232.00
(Size: 20 µl)
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MDM2 (pS260) Antibody is a Rabbit Polyclonal antibody against MDM2 (pS260). This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Research Articles on Mdm2 p53 Binding Protein Homolog Phospho-Ser260 (MDM2 pS260)
| Target | Mdm2 p53 Binding Protein Homolog Phospho-Ser260 (MDM2 pS260) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic phosphorylated peptide around S260 of human MDM2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q00987 (UniProt, ExPASy) |
| Gene Symbol | MDM2 |
| GeneID | 4193 |
| NCBI Accession | NP_001354919.1 |
| Molecular Weight | Calculated MW: 55 kDa Observed MW: 95 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |