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MEK1 (pS218 / 222) Antibody
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Catalogue No: abx031877
Price:
US$326.25
(Size: 80 µl)
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MEK1is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.
Research Articles on MEK1 (pS218/222)
| Target | MEK1 (pS218/222) |
| Clonality | Polyclonal |
| Target Modification | Ser218/222 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, DB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500, IHC-P: 1/50 - 1/100, DB: 1/500. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S218/222 of human MEK1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by protein G affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q02750 (UniProt, ExPASy) |
| UniProt Entry Name | MP2K1_HUMAN |
| KEGG | hsa:5604 |
| String | 9606.ENSP00000302486 |
| Molecular Weight | Calculated MW: 43.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Hamster, Drosophila, Xenopus and C. elegans MAP2K1. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |