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Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 (MEK3) Antibody
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Catalogue No: abx033761
Price:
US$326.25
(Size: 80 µl)
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MAP2K3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis.
Research Articles on Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 (MEK3)
| Target | Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 (MEK3) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 15-45 amino acids from the N-terminal region of human MEK3 (MAP2K3). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P46734 (UniProt, ExPASy) |
| UniProt Secondary AC | B3KSK7, Q99441, Q9UE71, Q9UE72 |
| UniProt Entry Name | MP2K3_HUMAN |
| NCBI Accession | NP_002747.2 NP_659731.1 |
| KEGG | hsa:5606 |
| String | 9606.ENSP00000345083 |
| Molecular Weight | Calculated MW: 39.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |