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Metabotropic Glutamate Receptor 3 Antibody
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Catalogue No: abx032807
Price:
US$326.25
(Size: 80 µl)
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L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 (also known as GPRC1C) while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The activity of GRM3 is mediated by a G-protein that inhibits adenylate cyclase activity.
Research Articles on Metabotropic Glutamate Receptor 3
| Target | Metabotropic Glutamate Receptor 3 |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 828-857 amino acids from the C-terminal region of human Metabotropic Glutamate Receptor 3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q14832 (UniProt, ExPASy) |
| UniProt Secondary AC | Q2PNZ6, Q75MV4, Q75N17, Q86YG6, Q8TBH9 |
| UniProt Entry Name | GRM3_HUMAN |
| KEGG | hsa:2913 |
| String | 9606.ENSP00000355316 |
| Molecular Weight | Calculated MW: 98.9 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Monkey GRM3. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |