+44 (0) 1223 755950
+1 832 327 7413
Metastasis-Suppressor KiSS-1 (KISS1) Antibody
REQUEST MORE INFO
Catalogue No: abx215870
Price:
US$406.00
(Size: 100 µg)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
Metastasis-Suppressor KiSS-1 (KISS1) Antibody is a Rabbit Polyclonal antibody for the detection of Kisspeptin. Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca (2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
Research Articles on Metastasis-Suppressor KiSS-1 (KISS1)
| Target | Metastasis-Suppressor KiSS-1 (KISS1) |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | IHC |
| Host | Rabbit |
| Recommended dilutions | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KiSS-1 metastasis-suppressor |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | Q15726 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K6N0, Q9HBP1 |
| UniProt Entry Name | KISS1_HUMAN |
| Gene Symbol | KISS1 |
| GeneID | 3814 |
| OMIM | 603286 |
| HGNC | 6341 |
| KEGG | hsa:3814 |
| Ensembl | ENSG00000170498 |
| String | 9606.ENSP00000356162 |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |