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MHC Class I Polypeptide Related Sequence A (MICA) Antibody
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Catalogue No: abx001216
Price:
US$348.00
(Size: 60 µl)
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MICA Antibody is a Rabbit Polyclonal antibody against MICA. MICA and MICB are stress-induced antigens that are related to major histocompatibility complex (MHC) class I molecules. MICA and MICB are frequently expressed in epithelial tumors. These highly glycosylated cell surface proteins are stably expressed without conventional class I peptide ligands or association with b-2-Microglobulin. The expression is induced on proliferating or heat shock-stressed epithelial cells. MICA and MICB are broadly recognized by intestinal epithelial Vd1 gd T cells expressing variable TCRs, suggesting that these antigens may play a central role in the signaling of cellular distress to evoke immune responses in the intestinal epithelium.
Research Articles on MHC Class I Polypeptide Related Sequence A (MICA)
| Target | MHC Class I Polypeptide Related Sequence A (MICA) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human MICA |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q29983 (UniProt, ExPASy) |
| UniProt Entry Name | MICA_HUMAN |
| Gene Symbol | MICA |
| GeneID | 4276 |
| NCBI Accession | NP_000238.1 |
| KEGG | hsa:100507436 |
| String | 9606.ENSP00000413079 |
| Molecular Weight | Calculated MW: 31 kDa/42 kDa Observed MW: 43 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |