Middle East Respiratory Syndrome Coronavirus Nucleocapsid (MERS-CoV N) Antibody

Middle East Respiratory Syndrome Coronavirus Nucleocapsid (MERS-CoV N) Antibody is a Mouse Monoclonal antibody for the detection of Middle East Respiratory Syndrome Coronavirus Nucleocapsid (MERS-CoV N).

Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.

Target	Middle East Respiratory Syndrome Coronavirus Nucleocapsid (MERS-CoV N)
Clonality	Monoclonal
Reactivity	Virus
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/1000 - 1/5000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant MERS-CoV Nucleoprotein / NP protein
Isotype	IgG1
Form	Liquid
Purification	Purified by Protein A affinity chromatography. 0.2 µm filtered.
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Buffer	PBS.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.
Directions for use	Centrifuge before opening to ensure complete recovery of vial contents.

Research Articles on Middle East Respiratory Syndrome Coronavirus Nucleocapsid (MERS-CoV N)

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